Epitalon vs MOTS-c
Longevity
Epitalon
Synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models.
Longevity
MOTS-c
16-amino-acid mitochondrial-derived peptide studied for AMPK activation and metabolic homeostasis.
Side by side
| Dimension | Epitalon | MOTS-c |
|---|---|---|
| Molecular weight A 5.6× difference in mass — these are not comparable on a milligram-for-milligram basis. | 390.35 g/mol | 2174.61 g/mol |
| Size class | small molecule / short peptide | mid-length peptide |
| CAS number | 307297-39-8 | 1627580-64-7 |
| Research area | longevity | longevity |
| Sequence | Ala-Glu-Asp-Gly | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Available sizes | 10mg, 50mg | 10mg |
| Entry price | $39 | $49 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $1.38 | $4.90 |
Mechanism
Epitalon
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research on pineal gland extracts. Published work has examined effects on telomerase expression in somatic cell cultures and circadian regulation in aged animals. A candid note on the evidence base: much of the foundational literature comes from a single institute and is not widely independently replicated. Researchers should weight it accordingly.
MOTS-c
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — one of a small class of mitochondrial-derived peptides that upended the assumption that the mitochondrial genome encodes only respiratory chain components. Research has focused on its translocation to the nucleus under metabolic stress and its role in AMPK-dependent signaling.
Research applications
Epitalon
- Telomerase activity assays in fibroblast culture
- Melatonin rhythm and pineal function studies
- Cellular senescence marker profiling
- Chromatin structure research in aged cell models
MOTS-c
- AMPK pathway activation studies
- Mitochondrial-nuclear retrograde signaling research
- Folate-methionine cycle interaction assays
- Exercise physiology and metabolic stress models
Common questions
What is the difference between Epitalon and MOTS-c?
Epitalon is synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models. MOTS-c is 16-amino-acid mitochondrial-derived peptide studied for AMPK activation and metabolic homeostasis. They differ in molecular weight (390.35 vs 2174.61 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, Epitalon or MOTS-c?
Epitalon is lower at approximately $1.38 per milligram at its best tier, against $4.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can Epitalon and MOTS-c be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should Epitalon and MOTS-c be stored?
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days. For MOTS-c: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.