Epitalon vs NAD+
Longevity
Epitalon
Synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models.
Longevity
NAD+
Essential redox coenzyme and substrate for sirtuins and PARPs — central to metabolic and DNA repair research.
Side by side
| Dimension | Epitalon | NAD+ |
|---|---|---|
| Molecular weight | 390.35 g/mol | 663.43 g/mol |
| Size class | small molecule / short peptide | short peptide |
| CAS number | 307297-39-8 | 53-84-9 |
| Research area | longevity | longevity |
| Sequence | Ala-Glu-Asp-Gly | Not published as a linear sequence |
| Available sizes | 10mg, 50mg | 500mg, 1000mg |
| Entry price | $39 | $59 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $1.38 | $0.11 |
Mechanism
Epitalon
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research on pineal gland extracts. Published work has examined effects on telomerase expression in somatic cell cultures and circadian regulation in aged animals. A candid note on the evidence base: much of the foundational literature comes from a single institute and is not widely independently replicated. Researchers should weight it accordingly.
NAD+
NAD+ is a dinucleotide coenzyme present in all living cells, functioning both as an electron carrier in redox reactions and as a consumed substrate for sirtuins, PARPs, and CD38. It is not a peptide. Research interest in the longevity context follows from the observation that tissue NAD+ concentration declines with age, and from the dependence of sirtuin activity on NAD+ availability.
Research applications
Epitalon
- Telomerase activity assays in fibroblast culture
- Melatonin rhythm and pineal function studies
- Cellular senescence marker profiling
- Chromatin structure research in aged cell models
NAD+
- Sirtuin activity and deacetylation assays
- PARP-mediated DNA repair studies
- Mitochondrial respiration and redox state measurement
- CD38 and NAD+ consumption pathway research
Common questions
What is the difference between Epitalon and NAD+?
Epitalon is synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models. NAD+ is essential redox coenzyme and substrate for sirtuins and PARPs — central to metabolic and DNA repair research. They differ in molecular weight (390.35 vs 663.43 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, Epitalon or NAD+?
NAD+ is lower at approximately $0.11 per milligram at its best tier, against $1.38 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can Epitalon and NAD+ be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should Epitalon and NAD+ be stored?
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days. For NAD+: Store lyophilized at -20°C protected from light and moisture. NAD+ is hygroscopic and degrades in solution faster than most peptides — prepare fresh where the assay permits.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.