Ipamorelin vs Tesamorelin
Growth Hormone
Ipamorelin
Highly selective pentapeptide ghrelin receptor agonist, notable for minimal cross-activation of other pituitary axes.
Growth Hormone
Tesamorelin
Stabilized 44-amino-acid GHRH analog — the longest GHRH sequence in common research use.
Side by side
| Dimension | Ipamorelin | Tesamorelin |
|---|---|---|
| Molecular weight A 7.2× difference in mass — these are not comparable on a milligram-for-milligram basis. | 711.85 g/mol | 5135.86 g/mol |
| Size class | short peptide | long peptide |
| CAS number | 170851-70-4 | 218949-48-5 |
| Research area | growth hormone | growth hormone |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 | Not published as a linear sequence |
| Available sizes | 5mg, 10mg | 10mg, 15mg |
| Entry price | $39 | $64 |
| Cost per mg | $4.90 | $5.93 |
Mechanism
Ipamorelin
Ipamorelin is a synthetic pentapeptide agonist at the growth hormone secretagogue receptor (GHS-R1a). Its defining research characteristic is selectivity: unlike earlier secretagogues such as GHRP-6 and GHRP-2, it shows minimal effect on ACTH, cortisol, and prolactin at comparable doses in animal models. That clean profile is precisely why it remains a useful tool compound for isolating GH-axis effects.
Tesamorelin
Tesamorelin is a synthetic analog of full-length human GHRH(1-44) with a trans-3-hexenoyl group attached at the N-terminus, conferring resistance to DPP-4 cleavage. It is distinguished from sermorelin and Modified GRF (1-29) by sequence length: those are truncated to the first 29 residues, whereas tesamorelin retains the complete 44-residue sequence. It has an established clinical literature, which is uncommon in this catalog.
Research applications
Ipamorelin
- GHS-R1a receptor selectivity and binding studies
- Pituitary somatotroph response assays
- Comparative secretagogue selectivity profiling
- Pulsatile secretion pattern research
Tesamorelin
- GHRH receptor binding and activation studies
- Comparative studies against truncated GHRH analogs
- Visceral adipose tissue metabolism research
- IGF-1 axis response profiling
Common questions
What is the difference between Ipamorelin and Tesamorelin?
Ipamorelin is highly selective pentapeptide ghrelin receptor agonist, notable for minimal cross-activation of other pituitary axes. Tesamorelin is stabilized 44-amino-acid GHRH analog — the longest GHRH sequence in common research use. They differ in molecular weight (711.85 vs 5135.86 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, Ipamorelin or Tesamorelin?
Ipamorelin is lower at approximately $4.90 per milligram at its best tier, against $5.93 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can Ipamorelin and Tesamorelin be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should Ipamorelin and Tesamorelin be stored?
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days. For Tesamorelin: Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.