Lyophilized powderIGF-1 LR3
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1)
IGF-1 LR3 is a recombinant analog of human IGF-1 carrying two modifications: an arginine substitution at position 3, and a 13-amino-acid N-terminal extension. The Arg3 substitution sharply reduces affinity for IGF binding proteins, which normally sequester the great majority of circulating IGF-1. The practical research consequence is a much larger free fraction and correspondingly extended activity — which also means potency comparisons against native IGF-1 are not straightforward.
Research applications
- IGF-1 receptor binding and autophosphorylation assays
- IGFBP interaction and displacement studies
- Cell proliferation and differentiation in culture
- Akt/mTOR pathway signaling research
Storage
Store lyophilized at -20°C protected from light. This is a larger protein than most of the catalog and is more sensitive to freeze-thaw; aliquot on first reconstitution.
Reconstitution
Reconstitute with bacteriostatic water or dilute acetic acid per protocol. Swirl gently; never vortex.
Published literature
16 papers indexed on PubMed for IGF-1 LR3. Showing 6, reviews first.
- 01IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep
White A et al. · Am J Physiol Endocrinol Metab · 2025
- 02
- 03
- 04Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
Lu Z et al. · Appl Microbiol Biotechnol · 2023
- 05Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets
White A et al. · J Dev Orig Health Dis · 2023
- 06N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling
Salvi R et al. · Int J Mol Sci · 2022
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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