5-Amino-1MQ vs Epitalon
Longevity
5-Amino-1MQ
Small-molecule NNMT inhibitor studied for effects on cellular methylation capacity and NAD+ salvage.
Longevity
Epitalon
Synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models.
Side by side
| Dimension | 5-Amino-1MQ | Epitalon |
|---|---|---|
| Molecular weight A 2.5× difference in mass — these are not comparable on a milligram-for-milligram basis. | 159.21 g/mol | 390.35 g/mol |
| Size class | small molecule / short peptide | small molecule / short peptide |
| CAS number | 42464-96-0 | 307297-39-8 |
| Research area | longevity | longevity |
| Sequence | Not published as a linear sequence | Ala-Glu-Asp-Gly |
| Available sizes | 10mg | 10mg, 50mg |
| Entry price | $49 | $39 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $4.90 | $1.38 |
Mechanism
5-Amino-1MQ
5-Amino-1MQ is a small-molecule quinolinium compound, not a peptide — worth stating plainly, since it is routinely sold alongside peptides. It is a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide and thereby diverts it away from the NAD+ salvage pathway. Research interest follows from NNMT overexpression in adipose tissue and the hypothesis that inhibition preserves both methyl donor pools and NAD+ precursor availability.
Epitalon
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research on pineal gland extracts. Published work has examined effects on telomerase expression in somatic cell cultures and circadian regulation in aged animals. A candid note on the evidence base: much of the foundational literature comes from a single institute and is not widely independently replicated. Researchers should weight it accordingly.
Research applications
5-Amino-1MQ
- NNMT enzyme inhibition and selectivity assays
- NAD+ salvage pathway flux studies
- S-adenosylmethionine and methyl donor pool measurement
- Adipocyte metabolic studies
Epitalon
- Telomerase activity assays in fibroblast culture
- Melatonin rhythm and pineal function studies
- Cellular senescence marker profiling
- Chromatin structure research in aged cell models
Common questions
What is the difference between 5-Amino-1MQ and Epitalon?
5-Amino-1MQ is small-molecule NNMT inhibitor studied for effects on cellular methylation capacity and NAD+ salvage. Epitalon is synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models. They differ in molecular weight (159.21 vs 390.35 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, 5-Amino-1MQ or Epitalon?
Epitalon is lower at approximately $1.38 per milligram at its best tier, against $4.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can 5-Amino-1MQ and Epitalon be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should 5-Amino-1MQ and Epitalon be stored?
Store at -20°C protected from light and moisture. For Epitalon: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.