Lyophilized powder5-Amino-1MQ
5-Amino-1-methylquinolinium (NNMT inhibitor)
5-Amino-1MQ is a small-molecule quinolinium compound, not a peptide — worth stating plainly, since it is routinely sold alongside peptides. It is a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide and thereby diverts it away from the NAD+ salvage pathway. Research interest follows from NNMT overexpression in adipose tissue and the hypothesis that inhibition preserves both methyl donor pools and NAD+ precursor availability.
Research applications
- NNMT enzyme inhibition and selectivity assays
- NAD+ salvage pathway flux studies
- S-adenosylmethionine and methyl donor pool measurement
- Adipocyte metabolic studies
Storage
Store at -20°C protected from light and moisture.
Reconstitution
Solubility differs from peptides — consult the COA for the appropriate solvent system rather than defaulting to bacteriostatic water.
Published literature
3 papers indexed on PubMed for 5-Amino-1MQ. Showing 3, reviews first.
- 01
- 02Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
Dimet-Wiley A et al. · Sci Rep · 2022
- 03Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells
Akar S et al. · J Obstet Gynaecol · 2021
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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