NAD+ vs 5-Amino-1MQ
Direct NAD+ supply against inhibition of the enzyme that depletes its precursor — two opposite strategies toward the same pool.
Longevity
NAD+
Essential redox coenzyme and substrate for sirtuins and PARPs — central to metabolic and DNA repair research.
Longevity
5-Amino-1MQ
Small-molecule NNMT inhibitor studied for effects on cellular methylation capacity and NAD+ salvage.
Side by side
| Dimension | NAD+ | 5-Amino-1MQ |
|---|---|---|
| Molecular weight A 4.2× difference in mass — these are not comparable on a milligram-for-milligram basis. | 663.43 g/mol | 159.21 g/mol |
| Size class | short peptide | small molecule / short peptide |
| CAS number | 53-84-9 | 42464-96-0 |
| Research area | longevity | longevity |
| Sequence | Not published as a linear sequence | Not published as a linear sequence |
| Available sizes | 500mg, 1000mg | 10mg |
| Entry price | $59 | $49 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $0.11 | $4.90 |
Mechanism
NAD+
NAD+ is a dinucleotide coenzyme present in all living cells, functioning both as an electron carrier in redox reactions and as a consumed substrate for sirtuins, PARPs, and CD38. It is not a peptide. Research interest in the longevity context follows from the observation that tissue NAD+ concentration declines with age, and from the dependence of sirtuin activity on NAD+ availability.
5-Amino-1MQ
5-Amino-1MQ is a small-molecule quinolinium compound, not a peptide — worth stating plainly, since it is routinely sold alongside peptides. It is a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide and thereby diverts it away from the NAD+ salvage pathway. Research interest follows from NNMT overexpression in adipose tissue and the hypothesis that inhibition preserves both methyl donor pools and NAD+ precursor availability.
Research applications
NAD+
- Sirtuin activity and deacetylation assays
- PARP-mediated DNA repair studies
- Mitochondrial respiration and redox state measurement
- CD38 and NAD+ consumption pathway research
5-Amino-1MQ
- NNMT enzyme inhibition and selectivity assays
- NAD+ salvage pathway flux studies
- S-adenosylmethionine and methyl donor pool measurement
- Adipocyte metabolic studies
Common questions
What is the difference between NAD+ and 5-Amino-1MQ?
NAD+ is essential redox coenzyme and substrate for sirtuins and PARPs — central to metabolic and DNA repair research. 5-Amino-1MQ is small-molecule NNMT inhibitor studied for effects on cellular methylation capacity and NAD+ salvage. They differ in molecular weight (663.43 vs 159.21 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, NAD+ or 5-Amino-1MQ?
NAD+ is lower at approximately $0.11 per milligram at its best tier, against $4.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can NAD+ and 5-Amino-1MQ be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should NAD+ and 5-Amino-1MQ be stored?
Store lyophilized at -20°C protected from light and moisture. NAD+ is hygroscopic and degrades in solution faster than most peptides — prepare fresh where the assay permits. For 5-Amino-1MQ: Store at -20°C protected from light and moisture.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.