CJC-1295 (no DAC) vs IGF-1 LR3
Growth Hormone
CJC-1295 (no DAC)
Modified GRF (1-29) analog with four amino acid substitutions conferring resistance to enzymatic degradation.
Growth Hormone
IGF-1 LR3
83-amino-acid IGF-1 analog engineered for markedly reduced binding to IGF binding proteins.
Side by side
| Dimension | CJC-1295 (no DAC) | IGF-1 LR3 |
|---|---|---|
| Molecular weight A 2.7× difference in mass — these are not comparable on a milligram-for-milligram basis. | 3367.9 g/mol | 9117.6 g/mol |
| Size class | mid-length peptide | protein-scale |
| CAS number | 863288-34-0 | 946870-92-4 |
| Research area | growth hormone | growth hormone |
| Sequence | Not published as a linear sequence | Not published as a linear sequence |
| Available sizes | 5mg, 10mg | 1mg |
| Entry price | $39 | $69 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $5.80 | $69.00 |
Mechanism
CJC-1295 (no DAC)
CJC-1295 without DAC — more precisely Modified GRF (1-29) — is a 29-amino-acid GHRH analog carrying four substitutions (D-Ala2, Gln8, Ala15, Leu27) that increase stability against DPP-4 cleavage and plasma degradation. The 'no DAC' designation distinguishes it from the drug affinity complex variant, which incorporates a maleimido group for albumin conjugation and a substantially longer half-life. The two are frequently conflated in supplier catalogs; they are pharmacokinetically very different molecules.
IGF-1 LR3
IGF-1 LR3 is a recombinant analog of human IGF-1 carrying two modifications: an arginine substitution at position 3, and a 13-amino-acid N-terminal extension. The Arg3 substitution sharply reduces affinity for IGF binding proteins, which normally sequester the great majority of circulating IGF-1. The practical research consequence is a much larger free fraction and correspondingly extended activity — which also means potency comparisons against native IGF-1 are not straightforward.
Research applications
CJC-1295 (no DAC)
- GHRH receptor binding and activation studies
- Comparative half-life studies against DAC-conjugated variants
- Combination studies with GHS-R1a agonists
- Enzymatic stability and degradation kinetics
IGF-1 LR3
- IGF-1 receptor binding and autophosphorylation assays
- IGFBP interaction and displacement studies
- Cell proliferation and differentiation in culture
- Akt/mTOR pathway signaling research
Common questions
What is the difference between CJC-1295 (no DAC) and IGF-1 LR3?
CJC-1295 (no DAC) is modified GRF (1-29) analog with four amino acid substitutions conferring resistance to enzymatic degradation. IGF-1 LR3 is 83-amino-acid IGF-1 analog engineered for markedly reduced binding to IGF binding proteins. They differ in molecular weight (3367.9 vs 9117.6 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, CJC-1295 (no DAC) or IGF-1 LR3?
CJC-1295 (no DAC) is lower at approximately $5.80 per milligram at its best tier, against $69.00 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can CJC-1295 (no DAC) and IGF-1 LR3 be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should CJC-1295 (no DAC) and IGF-1 LR3 be stored?
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days. For IGF-1 LR3: Store lyophilized at -20°C protected from light. This is a larger protein than most of the catalog and is more sensitive to freeze-thaw; aliquot on first reconstitution.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.