Epitalon vs SS-31
Longevity
Epitalon
Synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models.
Longevity
SS-31
Mitochondria-targeting tetrapeptide with high affinity for cardiolipin on the inner mitochondrial membrane.
Side by side
| Dimension | Epitalon | SS-31 |
|---|---|---|
| Molecular weight | 390.35 g/mol | 639.79 g/mol |
| Size class | small molecule / short peptide | short peptide |
| CAS number | 307297-39-8 | 736992-21-5 |
| Research area | longevity | longevity |
| Sequence | Ala-Glu-Asp-Gly | D-Arg-Dmt-Lys-Phe-NH2 |
| Available sizes | 10mg, 50mg | 10mg |
| Entry price | $39 | $49 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $1.38 | $4.90 |
Mechanism
Epitalon
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research on pineal gland extracts. Published work has examined effects on telomerase expression in somatic cell cultures and circadian regulation in aged animals. A candid note on the evidence base: much of the foundational literature comes from a single institute and is not widely independently replicated. Researchers should weight it accordingly.
SS-31
SS-31 is a cell-permeable tetrapeptide that concentrates in the inner mitochondrial membrane through interaction with cardiolipin, a phospholipid essential to cristae architecture and respiratory supercomplex assembly. Its alternating aromatic-cationic motif drives membrane targeting independent of mitochondrial membrane potential — a mechanistic distinction from earlier targeting strategies such as TPP+ conjugation.
Research applications
Epitalon
- Telomerase activity assays in fibroblast culture
- Melatonin rhythm and pineal function studies
- Cellular senescence marker profiling
- Chromatin structure research in aged cell models
SS-31
- Cardiolipin binding and cristae morphology studies
- Mitochondrial respiration and ATP synthesis assays
- Reactive oxygen species and oxidative stress models
- Ischemia-reperfusion injury research
Common questions
What is the difference between Epitalon and SS-31?
Epitalon is synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models. SS-31 is mitochondria-targeting tetrapeptide with high affinity for cardiolipin on the inner mitochondrial membrane. They differ in molecular weight (390.35 vs 639.79 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, Epitalon or SS-31?
Epitalon is lower at approximately $1.38 per milligram at its best tier, against $4.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can Epitalon and SS-31 be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should Epitalon and SS-31 be stored?
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days. For SS-31: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.