Lyophilized powderSS-31
SS-31 (Elamipretide)
SS-31 is a cell-permeable tetrapeptide that concentrates in the inner mitochondrial membrane through interaction with cardiolipin, a phospholipid essential to cristae architecture and respiratory supercomplex assembly. Its alternating aromatic-cationic motif drives membrane targeting independent of mitochondrial membrane potential — a mechanistic distinction from earlier targeting strategies such as TPP+ conjugation.
Research applications
- Cardiolipin binding and cristae morphology studies
- Mitochondrial respiration and ATP synthesis assays
- Reactive oxygen species and oxidative stress models
- Ischemia-reperfusion injury research
Storage
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water directed down the vial wall. Swirl gently.
Published literature
462 papers indexed on PubMed for SS-31. Showing 6, reviews first.
- 01Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Mendias CL, Awan TM · Sports Med · 2026
- 02Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential
Tung C et al. · Int J Mol Sci · 2025
- 03Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression
Pavlović N et al. · Cells · 2025
- 04Beyond the injection: delivery systems reshaping retinal disease management
Rowe LW et al. · Expert Opin Pharmacother · 2025
- 05Innovative technologies for the treatment of dry age-related macular degeneration (AMD) - modern therapeutic perspectives and their future
Ciszewski P et al. · Rom J Ophthalmol · 2025
- 06Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD)
Nashine S · Cells · 2021
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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