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DSIP — lyophilized powder in a sealed glass vial with crimp sealLyophilized powder

DSIP

DSIP (Delta Sleep-Inducing Peptide)

DSIP is a nonapeptide originally isolated in the 1970s from the cerebral venous blood of rabbits during induced sleep. Despite fifty years of intermittent study, no specific receptor has been identified and the mechanism remains genuinely unresolved — reported effects span sleep architecture, stress hormone modulation, and thermoregulation without a unifying pathway. Researchers should treat the mechanistic literature as unsettled rather than merely incomplete.

Research applications

  • Sleep architecture and EEG delta-wave studies in animal models
  • Corticotropin and stress axis interaction research
  • Thermoregulation studies

Storage

Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.

Reconstitution

Reconstitute with bacteriostatic water down the vial wall. Swirl gently.

Published literature

543 papers indexed on PubMed for DSIP. Showing 6, reviews first.

  1. 01
    Delta sleep-inducing peptide (DSIP): a still unresolved riddle

    Kovalzon VM, Strekalova TV · J Neurochem · 2006

    ReviewPMID 16539679doi:10.1111/j.1471-4159.2006.03693.x

  2. 02
    Delta sleep-inducing peptide

    Pollard BJ, Pomfrett CJ · Eur J Anaesthesiol · 2001

    ReviewPMID 11437870doi:10.1046/j.1365-2346.2001.00917.x

  3. 03
    Delta-sleep-inducing peptide (DSIP): an update

    Graf MV, Kastin AJ · Peptides · 1986

    ReviewPMID 3550726doi:10.1016/0196-9781(86)90148-8

  4. 04
    Delta-sleep-inducing peptide (DSIP): a review

    Graf MV, Kastin AJ · Neurosci Biobehav Rev · 1984

    ReviewPMID 6145137doi:10.1016/0149-7634(84)90022-8

  5. 05
    Delta sleep-inducing-peptide-like immunoreactivity (DSIP-LI) and delta sleep in schizophrenic volunteers

    van Kammen DP et al. · Sleep · 1992

    PMID 1475566doi:10.1093/sleep/15.6.519

  6. 06
    Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones

    Bjartell A et al. · Peptides · 1989

    PMID 2664725doi:10.1016/0196-9781(89)90093-4

Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.

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