Lyophilized powderGHK-Cu
GHK-Cu (Copper Peptide)
GHK is a tripeptide (glycyl-L-histidyl-L-lysine) present in human plasma that forms a high-affinity complex with copper(II). Plasma concentration declines markedly with age, which is the observation that originally drove research interest. Gene expression work has reported that GHK-Cu modulates a large number of human genes, and it is among the better-characterized peptides in dermatological and matrix biology literature.
Research applications
- Collagen and glycosaminoglycan synthesis assays
- Gene expression profiling in fibroblast cultures
- Metalloproteinase and antiprotease balance studies
- Copper transport and chelation research
Storage
Store lyophilized powder at -20°C protected from light. Characteristic blue coloration in solution is expected and indicates intact copper complexation.
Reconstitution
Reconstitute with bacteriostatic water. Solution will appear deep blue — this is the copper(II) complex, not contamination.
Published literature
140 papers indexed on PubMed for GHK-Cu. Showing 6, reviews first.
- 01Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF et al. · J Am Acad Orthop Surg Glob Res Rev · 2026
- 02Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Mayfield CK et al. · Am J Sports Med · 2026
- 03Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Mendias CL, Awan TM · Sports Med · 2026
- 04Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective
Mortazavi SM et al. · Bioimpacts · 2025
- 05Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Pickart L, Margolina A · Int J Mol Sci · 2018
- 06GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Pickart L et al. · Biomed Res Int · 2015
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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