Lyophilized powderTB-500
TB-500 (Thymosin Beta-4)
Thymosin beta-4 is a 43-amino-acid peptide and the principal G-actin sequestering molecule in mammalian cells. Its central mechanism is binding monomeric actin and regulating polymerization, which underlies its research relevance to cell motility, wound models, and angiogenesis. The actin-binding domain is localized to a short internal sequence (LKKTETQ), and some suppliers sell fragments of this region rather than the full peptide — a distinction worth confirming on any COA.
Research applications
- Actin polymerization and cytoskeletal dynamics assays
- Endothelial cell migration and tube formation studies
- Corneal and dermal wound model research
- Inflammatory cytokine modulation studies
Storage
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water directed down the vial wall. Swirl gently until fully dissolved.
Published literature
668 papers indexed on PubMed for TB-500. Showing 6, reviews first.
- 01Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF et al. · J Am Acad Orthop Surg Glob Res Rev · 2026
- 02Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Mayfield CK et al. · Am J Sports Med · 2026
- 03Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Mendias CL, Awan TM · Sports Med · 2026
- 04Neurotrophic keratopathy: current challenges and future prospects
NaPier E et al. · Ann Med · 2022
- 05Thymosin-β4: A key modifier of renal disease
Vasilopoulou E et al. · Expert Opin Biol Ther · 2018
- 06Thymosin β4 Promotes Dermal Healing
Kleinman HK, Sosne G · Vitam Horm · 2016
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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