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Glutathione — lyophilized powder in a sealed glass vial with crimp sealLyophilized powder

Glutathione

Glutathione (reduced, GSH)

Glutathione is a tripeptide with an unusual γ-peptide bond between glutamate and cysteine, which confers resistance to standard peptidase cleavage. Its free thiol group makes it the dominant intracellular redox buffer, and the GSH/GSSG ratio is a standard readout of cellular oxidative state. It is also an obligate cofactor for glutathione peroxidases and S-transferases.

Research applications

  • GSH/GSSG ratio measurement as an oxidative stress readout
  • Glutathione peroxidase and S-transferase activity assays
  • Xenobiotic conjugation and detoxification pathway studies
  • Ferroptosis research (GPX4 dependence on GSH)

Storage

Store lyophilized at -20°C protected from light. The free thiol oxidizes readily — minimize air exposure and prepare solutions fresh.

Reconstitution

Reconstitute with bacteriostatic water. Oxidation to GSSG begins on exposure to air; use promptly for redox-sensitive work.

Published literature

204,553 papers indexed on PubMed for Glutathione. Showing 6, reviews first.

  1. 01
    Glutathione

    Meister A, Anderson ME · Annu Rev Biochem · 1983

    ReviewPMID 6137189doi:10.1146/annurev.bi.52.070183.003431

  2. 02
    Efficient production of l-glutathione by whole-cell catalysis with ATP regeneration from adenosine

    Zuo S et al. · Biotechnol Bioeng · 2024

    PMID 38629468doi:10.1002/bit.28711

  3. 03
    The effect of reduced L-glutathione supplementation on TNF-α, hs-CRP, and neutrophil-lymphocyte ratio in maintenance hemodialysis patients

    Supriyadi R et al. · Eur Rev Med Pharmacol Sci · 2024

    PMID 39436083doi:10.26355/eurrev_202410_36828

  4. 04
    Cryptotanshinone alleviates lipopolysaccharide and cigarette smoke-induced chronic obstructive pulmonary disease in mice via the Keap1/Nrf2 axis

    Song H et al. · Biomed Pharmacother · 2023

    PMID 37399718doi:10.1016/j.biopha.2023.115105

  5. 05
    L-glutathione 1% promotes neuroprotection of nitrergic neurons and reduces the oxidative stress in the jejunum of rats with Walker-256-bearing tumor

    de Oliveira AP et al. · Neurogastroenterol Motil · 2023

    PMID 37831748doi:10.1111/nmo.14688

  6. 06
    The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial

    Duperray J et al. · J Cosmet Dermatol · 2022

    PMID 33834608doi:10.1111/jocd.14137

Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.

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