5-Amino-1MQ vs Glutathione
Longevity
5-Amino-1MQ
Small-molecule NNMT inhibitor studied for effects on cellular methylation capacity and NAD+ salvage.
Longevity
Glutathione
Endogenous thiol tripeptide and the principal intracellular antioxidant, central to redox buffering research.
Side by side
| Dimension | 5-Amino-1MQ | Glutathione |
|---|---|---|
| Molecular weight | 159.21 g/mol | 307.32 g/mol |
| Size class | small molecule / short peptide | small molecule / short peptide |
| CAS number | 42464-96-0 | 70-18-8 |
| Research area | longevity | longevity |
| Sequence | Not published as a linear sequence | γ-Glu-Cys-Gly |
| Available sizes | 10mg | 750mg, 1500mg |
| Entry price | $49 | $39 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $4.90 | $0.05 |
Mechanism
5-Amino-1MQ
5-Amino-1MQ is a small-molecule quinolinium compound, not a peptide — worth stating plainly, since it is routinely sold alongside peptides. It is a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide and thereby diverts it away from the NAD+ salvage pathway. Research interest follows from NNMT overexpression in adipose tissue and the hypothesis that inhibition preserves both methyl donor pools and NAD+ precursor availability.
Glutathione
Glutathione is a tripeptide with an unusual γ-peptide bond between glutamate and cysteine, which confers resistance to standard peptidase cleavage. Its free thiol group makes it the dominant intracellular redox buffer, and the GSH/GSSG ratio is a standard readout of cellular oxidative state. It is also an obligate cofactor for glutathione peroxidases and S-transferases.
Research applications
5-Amino-1MQ
- NNMT enzyme inhibition and selectivity assays
- NAD+ salvage pathway flux studies
- S-adenosylmethionine and methyl donor pool measurement
- Adipocyte metabolic studies
Glutathione
- GSH/GSSG ratio measurement as an oxidative stress readout
- Glutathione peroxidase and S-transferase activity assays
- Xenobiotic conjugation and detoxification pathway studies
- Ferroptosis research (GPX4 dependence on GSH)
Common questions
What is the difference between 5-Amino-1MQ and Glutathione?
5-Amino-1MQ is small-molecule NNMT inhibitor studied for effects on cellular methylation capacity and NAD+ salvage. Glutathione is endogenous thiol tripeptide and the principal intracellular antioxidant, central to redox buffering research. They differ in molecular weight (159.21 vs 307.32 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, 5-Amino-1MQ or Glutathione?
Glutathione is lower at approximately $0.05 per milligram at its best tier, against $4.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can 5-Amino-1MQ and Glutathione be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should 5-Amino-1MQ and Glutathione be stored?
Store at -20°C protected from light and moisture. For Glutathione: Store lyophilized at -20°C protected from light. The free thiol oxidizes readily — minimize air exposure and prepare solutions fresh.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.