Kisspeptin-10 vs KPV
Specialty
Kisspeptin-10
C-terminal decapeptide of kisspeptin, the upstream regulator of GnRH release via the KISS1R receptor.
Specialty
KPV
C-terminal tripeptide fragment of α-MSH studied for anti-inflammatory signaling without melanocortin receptor pigmentation effects.
Side by side
| Dimension | Kisspeptin-10 | KPV |
|---|---|---|
| Molecular weight A 3.8× difference in mass — these are not comparable on a milligram-for-milligram basis. | 1302.45 g/mol | 342.44 g/mol |
| Size class | short peptide | small molecule / short peptide |
| CAS number | 374675-21-5 | 67727-97-3 |
| Research area | specialty | specialty |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 | Lys-Pro-Val |
| Available sizes | 5mg | 10mg |
| Entry price | $39 | $49 |
| Cost per mg | $7.80 | $4.90 |
Mechanism
Kisspeptin-10
Kisspeptin-10 is the shortest fully active fragment of kisspeptin, the product of the KISS1 gene. Its discovery reframed reproductive neuroendocrinology: kisspeptin signaling through KISS1R (GPR54) sits upstream of GnRH neurons and is now understood as a gatekeeper of the reproductive axis. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism, which is the genetic evidence anchoring the pathway.
KPV
KPV is the C-terminal tripeptide (residues 11-13) of alpha-melanocyte-stimulating hormone. Its research interest stems from retaining anti-inflammatory activity attributed to the parent hormone while lacking the melanocortin receptor binding responsible for pigmentation effects — making it a useful tool for separating those two activities. Work has examined NF-κB pathway inhibition in intestinal epithelial models.
Research applications
Kisspeptin-10
- KISS1R (GPR54) receptor binding and activation assays
- GnRH pulse generation studies in hypothalamic models
- Reproductive axis and puberty-onset research
- Metastasis suppression studies (the original KISS1 context)
KPV
- NF-κB signaling pathway inhibition assays
- Intestinal epithelial inflammation models
- PepT1 transporter-mediated uptake studies
- Cytokine expression profiling
Common questions
What is the difference between Kisspeptin-10 and KPV?
Kisspeptin-10 is c-terminal decapeptide of kisspeptin, the upstream regulator of GnRH release via the KISS1R receptor. KPV is c-terminal tripeptide fragment of α-MSH studied for anti-inflammatory signaling without melanocortin receptor pigmentation effects. They differ in molecular weight (1302.45 vs 342.44 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, Kisspeptin-10 or KPV?
KPV is lower at approximately $4.90 per milligram at its best tier, against $7.80 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can Kisspeptin-10 and KPV be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should Kisspeptin-10 and KPV be stored?
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days. For KPV: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.