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KPV — lyophilized powder in a sealed glass vial with crimp sealLyophilized powder

KPV

KPV (α-MSH 11-13 tripeptide)

KPV is the C-terminal tripeptide (residues 11-13) of alpha-melanocyte-stimulating hormone. Its research interest stems from retaining anti-inflammatory activity attributed to the parent hormone while lacking the melanocortin receptor binding responsible for pigmentation effects — making it a useful tool for separating those two activities. Work has examined NF-κB pathway inhibition in intestinal epithelial models.

Research applications

  • NF-κB signaling pathway inhibition assays
  • Intestinal epithelial inflammation models
  • PepT1 transporter-mediated uptake studies
  • Cytokine expression profiling

Storage

Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.

Reconstitution

Reconstitute with bacteriostatic water directed down the vial wall. Swirl gently.

Published literature

81 papers indexed on PubMed for KPV. Showing 6, reviews first.

  1. 01
    A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon

    Zhao Y et al. · Acta Biomater · 2022

    PMID 35245681doi:10.1016/j.actbio.2022.02.039

  2. 02
    Are melanocortin peptides future therapeutics for cutaneous wound healing?

    Böhm M, Luger T · Exp Dermatol · 2019

    PMID 30661264doi:10.1111/exd.13887

  3. 03
    Structure-antifungal activity relationship of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues

    Masman MF et al. · Bioorg Med Chem · 2008

    PMID 18346897doi:10.1016/j.bmc.2008.02.072

  4. 04
    Anti-microbial action of melanocortin peptides and identification of a novel X-Pro-D/L-Val sequence in Gram-positive and Gram-negative bacteria

    Charnley M et al. · Peptides · 2008

    PMID 18355945doi:10.1016/j.peptides.2008.02.004

  5. 05
    PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation

    Dalmasso G et al. · Gastroenterology · 2008

    PMID 18061177doi:10.1053/j.gastro.2007.10.026

  6. 06
    Conformational analysis of tripeptide Ac-Lys-Pro-Val-NH2, COOH-terminal sequence of alpha-MSH

    Chavatte P et al. · J Pharm Pharmacol · 2001

    PMID 11480545doi:10.1211/0022357011776360

Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.

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