Lyophilized powderKisspeptin-10
Kisspeptin-10 (KP-10, metastin 45-54)
Kisspeptin-10 is the shortest fully active fragment of kisspeptin, the product of the KISS1 gene. Its discovery reframed reproductive neuroendocrinology: kisspeptin signaling through KISS1R (GPR54) sits upstream of GnRH neurons and is now understood as a gatekeeper of the reproductive axis. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism, which is the genetic evidence anchoring the pathway.
Research applications
- KISS1R (GPR54) receptor binding and activation assays
- GnRH pulse generation studies in hypothalamic models
- Reproductive axis and puberty-onset research
- Metastasis suppression studies (the original KISS1 context)
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water down the vial wall. Swirl gently.
Published literature
410 papers indexed on PubMed for Kisspeptin-10. Showing 6, reviews first.
- 01Roles of the kisspeptin/GPR54 system in pathomechanisms of atherosclerosis
Watanabe T, Sato K · Nutr Metab Cardiovasc Dis · 2020
- 02KISS1 in breast cancer progression and autophagy
Ulasov IV et al. · Cancer Metastasis Rev · 2019
- 03GPR54 and kisspeptin in reproduction
Tena-Sempere M · Hum Reprod Update · 2006
- 04
- 05
- 06
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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