PT-141 vs Kisspeptin-10
Melanocortin versus kisspeptin signaling. Both act centrally on reproductive pathways through unrelated receptor systems.
Specialty
PT-141
Cyclic heptapeptide melanocortin receptor agonist, a metabolite of melanotan II studied for central MC4R signaling.
Specialty
Kisspeptin-10
C-terminal decapeptide of kisspeptin, the upstream regulator of GnRH release via the KISS1R receptor.
Side by side
| Dimension | PT-141 | Kisspeptin-10 |
|---|---|---|
| Molecular weight | 1025.16 g/mol | 1302.45 g/mol |
| Size class | short peptide | short peptide |
| CAS number | 189691-06-3 | 374675-21-5 |
| Research area | specialty | specialty |
| Sequence | Not published as a linear sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Available sizes | 10mg | 5mg |
| Entry price | $44 | $39 |
| Cost per mg | $4.40 | $7.80 |
Mechanism
PT-141
PT-141 is a cyclic heptapeptide and the deaminated metabolite of melanotan II, acting as an agonist at melanocortin receptors with principal research interest at MC4R. Unlike melanotan II it lacks significant MC1R-mediated pigmentation activity, making it a cleaner tool for isolating MC4R-mediated central effects. Its mechanism is centrally mediated rather than vascular, which distinguishes it from PDE5-targeting compounds.
Kisspeptin-10
Kisspeptin-10 is the shortest fully active fragment of kisspeptin, the product of the KISS1 gene. Its discovery reframed reproductive neuroendocrinology: kisspeptin signaling through KISS1R (GPR54) sits upstream of GnRH neurons and is now understood as a gatekeeper of the reproductive axis. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism, which is the genetic evidence anchoring the pathway.
Research applications
PT-141
- MC4R and MC3R binding and selectivity assays
- Central melanocortin pathway signaling studies
- Comparative receptor profiling against melanotan II
Kisspeptin-10
- KISS1R (GPR54) receptor binding and activation assays
- GnRH pulse generation studies in hypothalamic models
- Reproductive axis and puberty-onset research
- Metastasis suppression studies (the original KISS1 context)
Common questions
What is the difference between PT-141 and Kisspeptin-10?
PT-141 is cyclic heptapeptide melanocortin receptor agonist, a metabolite of melanotan II studied for central MC4R signaling. Kisspeptin-10 is c-terminal decapeptide of kisspeptin, the upstream regulator of GnRH release via the KISS1R receptor. They differ in molecular weight (1025.16 vs 1302.45 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, PT-141 or Kisspeptin-10?
PT-141 is lower at approximately $4.40 per milligram at its best tier, against $7.80 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can PT-141 and Kisspeptin-10 be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should PT-141 and Kisspeptin-10 be stored?
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days. For Kisspeptin-10: Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.