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PT-141 — lyophilized powder in a sealed glass vial with crimp sealLyophilized powder

PT-141

PT-141 (Bremelanotide)

PT-141 is a cyclic heptapeptide and the deaminated metabolite of melanotan II, acting as an agonist at melanocortin receptors with principal research interest at MC4R. Unlike melanotan II it lacks significant MC1R-mediated pigmentation activity, making it a cleaner tool for isolating MC4R-mediated central effects. Its mechanism is centrally mediated rather than vascular, which distinguishes it from PDE5-targeting compounds.

Research applications

  • MC4R and MC3R binding and selectivity assays
  • Central melanocortin pathway signaling studies
  • Comparative receptor profiling against melanotan II

Storage

Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.

Reconstitution

Reconstitute with bacteriostatic water down the vial wall. Swirl gently.

Published literature

120 papers indexed on PubMed for PT-141. Showing 6, reviews first.

  1. 01
    Targeting the central melanocortin system for the treatment of metabolic disorders

    Sweeney P et al. · Nat Rev Endocrinol · 2023

    ReviewPMID 37365323doi:10.1038/s41574-023-00855-y

  2. 02
    Bremelanotide for Treatment of Female Hypoactive Sexual Desire

    Edinoff AN et al. · Neurol Int · 2022

    ReviewPMID 35076581doi:10.3390/neurolint14010006

  3. 03
    Medical Treatment of Female Sexual Dysfunction

    Nappi RE et al. · Urol Clin North Am · 2022

    ReviewPMID 35428435doi:10.1016/j.ucl.2022.02.001

  4. 04
    Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment

    Pettigrew JA, Novick AM · J Midwifery Womens Health · 2021

    ReviewPMID 34510696doi:10.1111/jmwh.13283

  5. 05
    Bremelanotide: First Approval

    Dhillon S, Keam SJ · Drugs · 2019

    ReviewPMID 31429064doi:10.1007/s40265-019-01187-w

  6. 06
    Bremelanotide

    Unknown · · 2012

    ReviewPMID 34436837

Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.

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