Kisspeptin-10 vs Thymosin Alpha-1
Specialty
Kisspeptin-10
C-terminal decapeptide of kisspeptin, the upstream regulator of GnRH release via the KISS1R receptor.
Specialty
Thymosin Alpha-1
28-amino-acid thymic peptide studied for Toll-like receptor signaling and T-cell maturation.
Side by side
| Dimension | Kisspeptin-10 | Thymosin Alpha-1 |
|---|---|---|
| Molecular weight A 2.4× difference in mass — these are not comparable on a milligram-for-milligram basis. | 1302.45 g/mol | 3108.3 g/mol |
| Size class | short peptide | mid-length peptide |
| CAS number | 374675-21-5 | 62304-98-7 |
| Research area | specialty | specialty |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 | Not published as a linear sequence |
| Available sizes | 5mg | 10mg |
| Entry price | $39 | $59 |
| Cost per mg | $7.80 | $5.90 |
Mechanism
Kisspeptin-10
Kisspeptin-10 is the shortest fully active fragment of kisspeptin, the product of the KISS1 gene. Its discovery reframed reproductive neuroendocrinology: kisspeptin signaling through KISS1R (GPR54) sits upstream of GnRH neurons and is now understood as a gatekeeper of the reproductive axis. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism, which is the genetic evidence anchoring the pathway.
Thymosin Alpha-1
Thymosin alpha-1 is a 28-amino-acid N-terminally acetylated peptide originally isolated from thymic tissue. It is among the better-characterized immunomodulatory peptides, with published mechanism centering on TLR2 and TLR9 signaling in dendritic cells and downstream effects on T-cell differentiation. Unlike much of this catalog, it has an established clinical literature under the name thymalfasin.
Research applications
Kisspeptin-10
- KISS1R (GPR54) receptor binding and activation assays
- GnRH pulse generation studies in hypothalamic models
- Reproductive axis and puberty-onset research
- Metastasis suppression studies (the original KISS1 context)
Thymosin Alpha-1
- TLR2 and TLR9 signaling assays in dendritic cell culture
- T-cell maturation and differentiation studies
- Cytokine profiling (IL-2, IFN-γ) in immune models
- Vaccine adjuvant research
Common questions
What is the difference between Kisspeptin-10 and Thymosin Alpha-1?
Kisspeptin-10 is c-terminal decapeptide of kisspeptin, the upstream regulator of GnRH release via the KISS1R receptor. Thymosin Alpha-1 is 28-amino-acid thymic peptide studied for Toll-like receptor signaling and T-cell maturation. They differ in molecular weight (1302.45 vs 3108.3 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, Kisspeptin-10 or Thymosin Alpha-1?
Thymosin Alpha-1 is lower at approximately $5.90 per milligram at its best tier, against $7.80 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can Kisspeptin-10 and Thymosin Alpha-1 be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should Kisspeptin-10 and Thymosin Alpha-1 be stored?
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days. For Thymosin Alpha-1: Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.