KPV vs PT-141
Specialty
KPV
C-terminal tripeptide fragment of α-MSH studied for anti-inflammatory signaling without melanocortin receptor pigmentation effects.
Specialty
PT-141
Cyclic heptapeptide melanocortin receptor agonist, a metabolite of melanotan II studied for central MC4R signaling.
Side by side
| Dimension | KPV | PT-141 |
|---|---|---|
| Molecular weight A 3.0× difference in mass — these are not comparable on a milligram-for-milligram basis. | 342.44 g/mol | 1025.16 g/mol |
| Size class | small molecule / short peptide | short peptide |
| CAS number | 67727-97-3 | 189691-06-3 |
| Research area | specialty | specialty |
| Sequence | Lys-Pro-Val | Not published as a linear sequence |
| Available sizes | 10mg | 10mg |
| Entry price | $49 | $44 |
| Cost per mg | $4.90 | $4.40 |
Mechanism
KPV
KPV is the C-terminal tripeptide (residues 11-13) of alpha-melanocyte-stimulating hormone. Its research interest stems from retaining anti-inflammatory activity attributed to the parent hormone while lacking the melanocortin receptor binding responsible for pigmentation effects — making it a useful tool for separating those two activities. Work has examined NF-κB pathway inhibition in intestinal epithelial models.
PT-141
PT-141 is a cyclic heptapeptide and the deaminated metabolite of melanotan II, acting as an agonist at melanocortin receptors with principal research interest at MC4R. Unlike melanotan II it lacks significant MC1R-mediated pigmentation activity, making it a cleaner tool for isolating MC4R-mediated central effects. Its mechanism is centrally mediated rather than vascular, which distinguishes it from PDE5-targeting compounds.
Research applications
KPV
- NF-κB signaling pathway inhibition assays
- Intestinal epithelial inflammation models
- PepT1 transporter-mediated uptake studies
- Cytokine expression profiling
PT-141
- MC4R and MC3R binding and selectivity assays
- Central melanocortin pathway signaling studies
- Comparative receptor profiling against melanotan II
Common questions
What is the difference between KPV and PT-141?
KPV is c-terminal tripeptide fragment of α-MSH studied for anti-inflammatory signaling without melanocortin receptor pigmentation effects. PT-141 is cyclic heptapeptide melanocortin receptor agonist, a metabolite of melanotan II studied for central MC4R signaling. They differ in molecular weight (342.44 vs 1025.16 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, KPV or PT-141?
PT-141 is lower at approximately $4.40 per milligram at its best tier, against $4.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can KPV and PT-141 be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should KPV and PT-141 be stored?
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days. For PT-141: Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.