KPV vs Thymosin Alpha-1
Specialty
KPV
C-terminal tripeptide fragment of α-MSH studied for anti-inflammatory signaling without melanocortin receptor pigmentation effects.
Specialty
Thymosin Alpha-1
28-amino-acid thymic peptide studied for Toll-like receptor signaling and T-cell maturation.
Side by side
| Dimension | KPV | Thymosin Alpha-1 |
|---|---|---|
| Molecular weight A 9.1× difference in mass — these are not comparable on a milligram-for-milligram basis. | 342.44 g/mol | 3108.3 g/mol |
| Size class | small molecule / short peptide | mid-length peptide |
| CAS number | 67727-97-3 | 62304-98-7 |
| Research area | specialty | specialty |
| Sequence | Lys-Pro-Val | Not published as a linear sequence |
| Available sizes | 10mg | 10mg |
| Entry price | $49 | $59 |
| Cost per mg | $4.90 | $5.90 |
Mechanism
KPV
KPV is the C-terminal tripeptide (residues 11-13) of alpha-melanocyte-stimulating hormone. Its research interest stems from retaining anti-inflammatory activity attributed to the parent hormone while lacking the melanocortin receptor binding responsible for pigmentation effects — making it a useful tool for separating those two activities. Work has examined NF-κB pathway inhibition in intestinal epithelial models.
Thymosin Alpha-1
Thymosin alpha-1 is a 28-amino-acid N-terminally acetylated peptide originally isolated from thymic tissue. It is among the better-characterized immunomodulatory peptides, with published mechanism centering on TLR2 and TLR9 signaling in dendritic cells and downstream effects on T-cell differentiation. Unlike much of this catalog, it has an established clinical literature under the name thymalfasin.
Research applications
KPV
- NF-κB signaling pathway inhibition assays
- Intestinal epithelial inflammation models
- PepT1 transporter-mediated uptake studies
- Cytokine expression profiling
Thymosin Alpha-1
- TLR2 and TLR9 signaling assays in dendritic cell culture
- T-cell maturation and differentiation studies
- Cytokine profiling (IL-2, IFN-γ) in immune models
- Vaccine adjuvant research
Common questions
What is the difference between KPV and Thymosin Alpha-1?
KPV is c-terminal tripeptide fragment of α-MSH studied for anti-inflammatory signaling without melanocortin receptor pigmentation effects. Thymosin Alpha-1 is 28-amino-acid thymic peptide studied for Toll-like receptor signaling and T-cell maturation. They differ in molecular weight (342.44 vs 3108.3 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, KPV or Thymosin Alpha-1?
KPV is lower at approximately $4.90 per milligram at its best tier, against $5.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can KPV and Thymosin Alpha-1 be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should KPV and Thymosin Alpha-1 be stored?
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days. For Thymosin Alpha-1: Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.
All products are intended strictly for laboratory research use. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, or cosmetic.
Comparison generated from NuVida Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.